Hyperoxaluria is the state of having too much total oxalate in the urine, from both endogenous (internal) production and dietary intake.

Regulation is different in cerebro-spinal fluid (CSF), urine, and blood plasma.

Diagram of the Glyoxylate metabolism in the liver.

What happens chemically when oxalate metabolism is in B6 deficiency.

A healthy sulfur chemistry protects us from making too much endogenous oxalate.  It is not just about what we eat, it’s the sum of what we eat plus what we make.

An Environmental hit (such as medication, illness, or vaccine) can cause AGT dysfunction as described in the box at the bottom of the diagram.

Urine oxalate values in children with autism were found to be dramatically higher than unaffected children.

Soy is high in oxalates.  Soy is found in a wide variety of processed foods.

This poster explains the low oxalate diet for autism.  It is most easily read in the handout.

Joyce Graff, Powerful Patient

Mike Lawing, Powerful Patient

Podcast: Play in new window | Download (Duration: 30:37 — 17.3MB)

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Oxalate is an antinutrient that is present at higher levels in some plant foods like spinach, nuts, and chocolate, but it is also a mitochondrial toxin and neurotoxin, and impairs calcium and iron regulation, all biotin-dependent enzymes, and many other enzymes. — Susan Costen Owens

Susan Costen Owens has lectured widely, both nationally and internationally. This graduate of Vanderbilt University with a masters degree in Interdisciplinary Studies from the University of Texas in Dallas has fifteen years of experience in autism research. She realized in 2009 that the gut inflammation and leaky gut in autism and other developmental disorders would lead to increased absorption of oxalate from the diet with unknown consequences.

Through her project at the Autism Research Institute, this diet has led to the loss of the autism diagnosis in some children and improvements in pain, cognition, growth, motor skills, gastrointestinal function, and social interaction in countless others. Her internet group, Trying Low Oxalates, has grown to more than 3000 people, including those with celiac disease, cystic fibrosis, myotonic dystrophy, Rett syndrome, MHE, bariatric surgery, short bowel syndrome, chronic pain syndromes like fibromyalgia, vulvodynia and bone pain, chronic fatigue, autoimmune conditions, and many other conditions, taking the study of oxalate’s relationship to disease far beyond the familiar turf of kidney stone disease.

The slide show including the poster is available at https://powerfulpatient.org/handouts/owens-re-oxalate.pdf

See also http://www.lowoxalate.info/